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DiLeone et al., Mesolimbic reward system GLP-1 receptor expression Already in 1999 the first neuroanatomical indication for a potential role of GLP-1 in reward emerged
Peptide predictor Instead of manually isolating proteins and peptides from tissues and using techniques like mass spectrometry to identify hundreds of thousands of peptides, the researchers designed a computer algorithm they named Peptide Predictor to identify typical prohormone convertase cleavage sites in all 20,000 human protein-coding genes
Zepbound, also a once-weekly injection, was approved in 2023 and showed up to 22.5% average weight loss in trials, making it the most effective option currently available
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